NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland
نویسندگان
چکیده
منابع مشابه
[Morphological aspects on the site of iodination of thyroglobulin in the thyroid gland].
The site of iodination of thyroglobulin in the thyroid gland revealed through morphological studies was critically reviewed in relationship to biochemical points of view. The phylogenetic and evolutional aspects of this problem were also reviewed and discussed. To conclude, the present author wishes to emphasize the following: 1. In adult vertebrates whose thyroid follicular structure has been ...
متن کاملIodination and oxidation of thyroglobulin catalyzed by thyroid peroxidase.
The kinetics of iodination and oxidation of hog thyroglobulin were studied with purified hog thyroid peroxidase and the results were compared with the reactions of free tyrosine. From Lineweaver-Burk plots and on the basis of a value of 0.83 for delta epsilon mM at 289 nm/iodine atom incorporated, the rate constant for transfer of an assumed enzyme-bound iodinium cation to thyroglobulin was est...
متن کاملDevelopmental Expression of the Nfe2-Related Factor (Nrf) Transcription Factor Family in the Zebrafish, Danio rerio
Transcription factors in the CNC-bZIP family (NFE2, NRF1, NRF2 and NRF3) regulate genes with a wide range of functions in response to both physiological and exogenous signals, including those indicating changes in cellular redox status. Given their role in helping to maintain cellular homeostasis, it is imperative to understand the expression, regulation, and function of CNC-bZIP genes during e...
متن کاملNon-thyroglobulin Iodine of the Thyroid Gland
Thyroxine in the thyroid gland is considered to be firmly built into the protein molecule, thyroglobulin (1). Only after the gland is hydrolyzed with fairly strong alkali does its thyroxine become readily extractable with butyl alcohol. The iodine which circulates in plasma, on the other hand, can be almost completely extracted with butyl alcohol without previous hydrolysis (2). Considerable ev...
متن کاملDefective thyroglobulin synthesis in an experimental rat thyroid tumor: iodination and thyroid hormone synthesis in isolated tumor thyroglobulin.
Purified rat tumor thyroglobulin from the experimental rat thyroid tumor, line 1-1C2, was studied for its thyroid hormone content after in vivo and in vitro iodination and compared with normal and desialylated normal rat thyroglobulin. Tumor thyroglobulin had a very low sialic acid and iodine content; after in vivo iodination it contained only small amounts of triiodothyronine (T3) and no detec...
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ژورنال
عنوان ژورنال: Thyroid
سال: 2018
ISSN: 1050-7256,1557-9077
DOI: 10.1089/thy.2018.0018